細(xì)胞色素C單克隆抗體
- 發(fā)布日期： 2023-11-21
- 更新日期： 2025-10-10
產(chǎn)品詳請(qǐng)
| 產(chǎn)地 |
上海
|
| 品牌 |
森興研
|
| 保存條件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
|
| 貨號(hào) |
|
| 用途 |
科研
|
| 應(yīng)用范圍 |
WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
|
| 抗原來源 |
Mouse
|
| 保質(zhì)期 |
|
| 抗體名 |
Cytochrome C
|
| 是否單克隆 |
|
| 克隆性 |
是
|
| 靶點(diǎn) |
|
| 適應(yīng)物種 |
咨詢
|
| 形態(tài) |
Liquid
|
| 宿主 |
咨詢
|
| 標(biāo)記物 |
|
| 包裝規(guī)格 |
100ul
|
| 亞型 |
IgG
|
| 標(biāo)識(shí)物 |
|
| 濃度 |
1mg/ml%
|
| 免疫原 |
Recombinant human Cytochrome C Protein
|
| 是否進(jìn)口 |
|
研究領(lǐng)域腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞凋亡 線粒體
抗體來源Mouse
克隆類型Monoclonal
克 隆 號(hào)6B10
交叉反應(yīng)Human, Mouse, Rat,
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量12kDa
檢測(cè)分子量14.4kDa
細(xì)胞定位細(xì)胞漿 線粒體
性 狀Liquid
濃 度1mg/ml
免 疫 原Recombinant human Cytochrome C Protein
亞 型IgG
純化方法affinity purified by Protein G
緩 沖 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Subcellular Location:
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Post-translational modifications:
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
DISEASE:
Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Similarity:
Belongs to the cytochrome c family.
SWISS:
P99999
Gene ID:
54205
