中文名稱基質金屬蛋白酶3重組兔單抗
別 名MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3 (MMP-3); MMP-3; MMP 3; Transin-1;
研究領域腫瘤
抗體來源Rabbit
克隆類型Monoclonal
交叉反應Human, (predicted: Mouse, Rat, )
產品應用WB=1:500-1000 IHC-P=1:100-500 Flow-Cyt=1:100 ICC=1:50 IF=1:50-100 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量54kDa
細胞定位細胞外基質 分泌型蛋白
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MMP-3
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產品介紹Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].
Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).
Similarity:
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
SWISS:
P08254
Gene ID:
4314
