甲狀腺激素受體β抗體
- 發(fā)布日期： 2023-11-16
- 更新日期： 2025-10-10
產(chǎn)品詳請(qǐng)
| 產(chǎn)地 |
上海
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| 品牌 |
森興研
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| 保存條件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
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| 貨號(hào) |
|
| 用途 |
科研
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| 應(yīng)用范圍 |
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user
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| 抗原來源 |
Rabbit
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| 保質(zhì)期 |
|
| 抗體名 |
THRB1
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| 是否單克隆 |
否
|
| 克隆性 |
是
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| 靶點(diǎn) |
|
| 適應(yīng)物種 |
咨詢
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| 形態(tài) |
Liquid
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| 宿主 |
|
| 標(biāo)記物 |
|
| 包裝規(guī)格 |
100ul
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| 亞型 |
IgG
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| 標(biāo)識(shí)物 |
|
| 濃度 |
1mg/ml%
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| 免疫原 |
KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta: 201-300/461
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| 是否進(jìn)口 |
否
|
研究領(lǐng)域心血管 細(xì)胞生物 神經(jīng)生物學(xué) 生長因子和激素 內(nèi)分泌病
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, (predicted: Chicken, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量53 kDa
細(xì)胞定位細(xì)胞核
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta: 201-300/461
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.
Function:
High affinity receptor for triiodothyronine.
Subunit:
Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA7 in a ligand-inducible manner. Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP.
Subcellular Location:
Nucleus.
DISEASE:
Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
SWISS:
P10828
Gene ID:
7068
