CD8β鏈（CD8-β）抗體
- 發(fā)布日期： 2023-11-07
- 更新日期： 2025-10-10
產(chǎn)品詳請
| 產(chǎn)地 |
上海
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| 品牌 |
森興研
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| 保存條件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
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| 貨號 |
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| 用途 |
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| 應用范圍 |
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
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| 抗原來源 |
Rabbit
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| 保質(zhì)期 |
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| 抗體名 |
CD8B
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| 是否單克隆 |
否
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| 克隆性 |
是
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| 靶點 |
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| 適應物種 |
咨詢
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| 形態(tài) |
Liquid
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| 宿主 |
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| 標記物 |
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| 包裝規(guī)格 |
100ul
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| 亞型 |
IgG
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| 標識物 |
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| 濃度 |
1mg/ml%
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| 免疫原 |
KLH conjugated synthetic peptide derived from human CD8B: 51-150/210 <Extracellular>
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| 是否進口 |
否
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英文名稱CD8B
中文名稱CD8β鏈（CD8-β）抗體
別 名CD8b antigen; T cell surface glycoprotein CD8 beta chain; CD8 antigen beta polypeptide 1 (p37); CD8 antigen beta polypeptide 1; CD8 beta; CD8b; CD8b molecule; CD8B_HUMAN; CD8B1; Leu2; Ly3; LYT3; MGC119115; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain.
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, (predicted: Chicken, Pig, Horse, Guinea Pig, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量21kDa
細胞定位細胞膜 分泌型蛋白
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD8B: 51-150/210 <Extracellular>
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Subunit:
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.
Subcellular Location:
Isoform 1, 2, 4, 5:Cell membrane; Single-pass type I membrane protein. Isoform 3, 6, 7, 8: Secreted.
Tissue Specificity:
Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
P10966
Gene ID:
926
