核因子2相關因子2抗體
- 發布日期： 2023-11-07
- 更新日期： 2025-10-10
產品詳請
| 產地 |
上海
|
| 品牌 |
森興研
|
| 保存條件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
|
| 貨號 |
|
| 用途 |
|
| 應用范圍 |
WB=1:100-1000 ELISA=1:1000-5000 IHC-P=1:100-1000 IHC-F=1:100-1000 ICC=1:100 IF=1:100-1000 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
|
| 抗原來源 |
Rabbit
|
| 保質期 |
|
| 抗體名 |
Nrf2
|
| 是否單克隆 |
否
|
| 克隆性 |
是
|
| 靶點 |
|
| 適應物種 |
|
| 形態 |
Liquid
|
| 宿主 |
|
| 標記物 |
|
| 包裝規格 |
100ul
|
| 亞型 |
IgG
|
| 標識物 |
|
| 濃度 |
1mg/ml%
|
| 免疫原 |
KLH conjugated synthetic peptide derived from human Nrf2: 401-500/605
|
| 是否進口 |
否
|
研究領域腫瘤 免疫學 染色質和核信號 合成與降解
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, (predicted: Chicken, Dog, Cow, Horse, Rabbit, )
產品應用WB=1:100-1000 ELISA=1:1000-5000 IHC-P=1:100-1000 IHC-F=1:100-1000 ICC=1:100 IF=1:100-1000 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量68kDa
細胞定位細胞核 細胞漿
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nrf2: 401-500/605
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產品介紹Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Subunit:
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Tissue Specificity:
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Post-translational modifications:
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
SWISS:
Q16236
Gene ID:
4780
